Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders

被引：1

作者：

Ivanova, A. V. ^{[1
]}

Gerasimova, E. L. ^{[1
]}

Gazizullina, E. R. ^{[1
]}

Okulova, Ya. A. ^{[1
]}

Matern, A. I. ^{[1
]}

Rusinov, V. L. ^{[1
]}

机构：

[1] BN Yeltsin Ural Fed Univ, Inst Chem Technol, 19 Mir St, Ekaterinburg 620002, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 08期

基金：

俄罗斯科学基金会;

关键词：

antioxidant activity; antiradical activity; potentiometry; CATARACT;

D O I：

10.1007/s11094-018-1883-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dosage forms intended for ophthalmic use with declared and potential antioxidant properties were investigated. Antioxidant activity was determined using potentiometry with potassium hexacyanoferrate (III) as the oxidant. Antiradical activity was studied using the stable radical 2,2-diphenyl-1-picrylhydrazyl. The reaction half-lives of the investigated dosage forms were determined. Ratios of the experimental antioxidant activity to the content of main active ingredient were assessed.

引用

页码：694 / 699

页数：6

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