Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

被引:39
作者
Gaynanova, Gulnara [1 ]
Vasileva, Leysan [1 ]
Kashapov, Ruslan [1 ]
Kuznetsova, Darya [1 ]
Kushnazarova, Rushana [1 ]
Tyryshkina, Anna [1 ]
Vasilieva, Elmira [1 ]
Petrov, Konstantin [1 ]
Zakharova, Lucia [1 ]
Sinyashin, Oleg [1 ]
机构
[1] Russian Acad Sci, Arbuzov Inst Organ & Phys Chem, FRC Kazan Sci Ctr, Arbuzov St 8, Kazan 420088, Russia
来源
MOLECULES | 2021年 / 26卷 / 22期
基金
俄罗斯科学基金会;
关键词
biological barrier; surfactant; nanocontainer; nanoparticle; micelle; niosome; transfersome; chitosome; invasome; ENHANCED TRANSDERMAL DELIVERY; IN-VITRO CHARACTERIZATION; ACID-BASED SURFACTANTS; SKIN PENETRATION; LIPOSOMAL FORMULATIONS; CATIONIC SURFACTANTS; GEMINI SURFACTANTS; TOPICAL DELIVERY; PHYSICOCHEMICAL PROPERTIES; STATISTICAL OPTIMIZATION;
D O I
10.3390/molecules26226786
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.
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页数:40
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