Visible-Light-Driven Bisfunctionalization of Unactivated Olefins via the Merger of Proton-Coupled Electron Transfer and Carbene Catalysis

被引：48

作者：

Zhang, Bei ^{[1
]}

Qi, Jian-Qing ^{[1
]}

Liu, Yuhan ^{[1
]}

Li, Zhipeng ^{[1
]}

Wang, Jian ^{[1
]}

机构：

[1] Tsinghua Univ, Ctr Basic Mol Sci CBMS, Sch Pharmaceut Sci,Dept Chem, Key Lab Bioorgan Phosphorous Chem & Chem Biol,Min, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CYCLOPROPANATION; ALKYLATION; ESTERS;

D O I：

10.1021/acs.orglett.1c03941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we reported an N-heterocyclic carbene (NHC) and photo-co-catalyzed alkylacylation of olefins in the presence of the versatile synthon diazo ester, providing a new idea for transient radical generation with the only byproduct being N-2. Particularly, this radical process employs traditional carbene precursor diazo esters as the radical source, which is the first case in NHC catalysis. Compared to the previous pathway that produces radicals with large discard fragments, this merged channel possesses great atom economy.

引用

页码：279 / 283

页数：5

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