Alkyl Propiolates Participated [3+2] Annulation for the Switchable Synthesis of 1,5-and 1,4-Disubstituted 1,2,3-Triazoles Containing Ester Side Chain

被引：28

作者：

Cao, Shuo ^{[1
]}

Liu, Yunyun ^{[1
]}

Hu, Changfeng ^{[2
]}

Wen, Chengping ^{[2
]}

Wan, Jie-Ping ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou 310053, Zhejiang, Peoples R China

来源：

CHEMCATCHEM | 2018年 / 10卷 / 21期

基金：

中国国家自然科学基金;

关键词：

alkyl propiolate; annulation; enamine activation; switchable; 1,2,3-triazoles; METAL-FREE; 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES; REGIOSELECTIVE SYNTHESIS; 1,4,5-TRISUBSTITUTED 1,2,3-TRIAZOLES; 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLES; SUBSTITUTED 1,2,3-TRIAZOLES; MULTICOMPONENT REACTIONS; REGIOSPECIFIC SYNTHESIS; CYCLOADDITION REACTIONS; PROMOTED SYNTHESIS;

D O I：

10.1002/cctc.201801366

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

By means of a featured enamine activation, the alkyl propiolates have been successfully employed in the [3+2] annulation for the synthesis of 1,2,3-triazoles. The synthesis of both 1,4- as well as the hardly available 1,5-disubstituted 1,2,3-triazoles can be selectively accessed by using tosyl azide and tosyl hydrazine as nitrogen source, respectively.

引用

页码：5021 / 5025

页数：5

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