Applying nanomedicine in maladaptive inflammation and angiogenesis

被引：44

作者：

Alaarg, Amr ^{[1
,2
,3
]}

Perez-Medina, Carlos ^{[1
]}

Metselaar, Josbert M. ^{[2
,4
]}

Nahrendorf, Matthias ^{[5
]}

Fayad, Zahi A. ^{[1
]}

Storm, Gert ^{[2
,3
]}

Mulder, Willem J. M. ^{[1
,6
]}

机构：

[1] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, One Gustave L Levy Pl,Box 1234, New York, NY 10029 USA

[2] Univ Twente, Dept Biomat Sci & Technol, MIRA Inst Biomed Technol & Tech Med, Enschede, Netherlands

[3] Univ Utrecht, Dept Pharmaceut, UIPS, Fac Sci, Utrecht, Netherlands

[4] Univ Clin, Inst Expt Mol Imaging, Helmholtz Inst Biomed Engn, Aachen, Germany

[5] Harvard Med Sch, Ctr Syst Biol, Massachusetts Gen Hosp, Boston, MA USA

[6] Acad Med Ctr, Dept Med Biochem, Amsterdam, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2017年 / 119卷

基金：

美国国家卫生研究院;

关键词：

Monocytes; Macrophages; Chronic inflammation; Immunomodulation; Atherosclerosis; Cancer; Angiogenesis; Nanomedicine; Molecular imaging; Targeted drug delivery; TUMOR-ASSOCIATED MACROPHAGES; ULTRASMALL SUPERPARAMAGNETIC PARTICLES; TARGETED FUMAGILLIN NANOPARTICLES; PATTERN-RECOGNITION RECEPTORS; ENDOTHELIAL GROWTH-FACTOR; BONE-MARROW ANGIOGENESIS; NF-KAPPA-B; MAGNETIC-RESONANCE; RHEUMATOID-ARTHRITIS; BREAST-CANCER;

D O I：

10.1016/j.addr.2017.05.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease. Though these diseases have very different phenotypic consequences, they possess several common pathophysiological features in which monocyte recruitment, macrophage polarization, and enhanced vascular permeability play critical roles. Thus, developing rational targeting strategies tailored to the different stages of the journey of monocytes, from bone marrow to local lesions, and their extravasation from the vasculature in diseased tissues will advance nanomedicine. The integration of in vivo imaging uniquely allows studying nanoparticle kinetics, accumulation, clearance, and biological activity, at levels ranging from subcellular to an entire organism, and will shed light on the fate of intravenously administered nanomedicines. We anticipate that convergence of nanomedicines, biomedical engineering, and life sciences will help to advance clinically relevant therapeutics and diagnostic agents for patients with chronic inflammatory diseases. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：143 / 158

页数：16

共 280 条

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