Suppression of stress-induced nNOS expression in the rat hypothalamus by biting

被引：38
作者：
Hori, N
Lee, MC
Sasaguri, K
Ishii, H
Kamei, M
Kimoto, K
Toyoda, M
Sato, S
机构：
[1] Kanagawa Dent Coll, Div Pharmacol, Yokosuka, Kanagawa 2388580, Japan
[2] Kanagawa Dent Coll, ESR Labs, Yokosuka, Kanagawa 2388580, Japan
[3] Kanagawa Dent Coll, Div Prosthet, Yokosuka, Kanagawa 2388580, Japan
来源：
JOURNAL OF DENTAL RESEARCH | 2005年 / 84卷 / 07期
关键词：
neuronal nitric oxide synthase (nNOS); restraint stress; biting; paraventricular nucleus; rat;
D O I：
10.1177/154405910508400708
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Nitric oxide ((.) NO) modulates the activity of the endocrine system in the behavioral response to stress. The purpose of this study was to investigate the effect of restraining the body of an animal on expression of neuronal nitric oxide synthase ( nNOS) in the paraventricular nucleus ( PVN) of the hypothalamus, and the inhibitory effect of para- masticatory activity on restraint- induced nNOS expression. We observed an increase in nNOS mRNA expression and nNOS- positive neurons in the rat hypothalamus after 30 or 60 min of restraint. Biting on a wooden stick during bodily restraint decreased nNOS mRNA expression in the hypothalamus. In addition, the number of nNOS- positive neurons was significantly reduced in the PVN of the hypothalamus. These observations clearly suggest a possible anti- stress effect of the masticatory activity of biting, and this mechanism might be unconsciously in operation during exposure to psychological stressors.
引用
收藏
页码：624 / 628
页数：5
相关论文
共 31 条
[1]   NOS MESSENGER-RNA IN THE PARAVENTRICULAR NUCLEUS OF YOUNG AND OLD RATS AFTER IMMOBILIZATION STRESS [J].
CALZA, L ;
GIARDINO, L ;
CECCATELLI, S .
NEUROREPORT, 1993, 4 (06) :627-630
[2]   DISTRIBUTION AND COEXISTENCE OF CORTICOTROPIN-RELEASING FACTOR-LIKE, NEUROTENSIN-LIKE, ENKEPHALIN-LIKE, CHOLECYSTOKININ-LIKE, GALANIN-LIKE AND VASOACTIVE INTESTINAL POLYPEPTIDE PEPTIDE HISTIDINE ISOLEUCINE-LIKE PEPTIDES IN THE PARVOCELLULAR PART OF THE PARAVENTRICULAR NUCLEUS [J].
CECCATELLI, S ;
ERIKSSON, M ;
HOKFELT, T .
NEUROENDOCRINOLOGY, 1989, 49 (03) :309-323
[3]   THE DETERMINATION OF AN EMPIRICAL CORRECTION FACTOR TO DEAL WITH THE PROBLEM OF NUCLEOLAR SPLITTING IN NEURONAL COUNTS [J].
COGGESHALL, RE ;
CHUNG, K .
JOURNAL OF NEUROSCIENCE METHODS, 1984, 10 (02) :149-155
[4]   NITRIC-OXIDE MODULATES THE RELEASE OF CORTICOTROPIN-RELEASING HORMONE FROM THE RAT HYPOTHALAMUS INVITRO [J].
COSTA, A ;
TRAINER, P ;
BESSER, M ;
GROSSMAN, A .
BRAIN RESEARCH, 1993, 605 (02) :187-192
[5]   ANATOMICAL SPECIFICITY OF NORADRENERGIC INPUTS TO THE PARAVENTRICULAR AND SUPRAOPTIC NUCLEI OF THE RAT HYPOTHALAMUS [J].
CUNNINGHAM, ET ;
SAWCHENKO, PE .
JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 274 (01) :60-76
[6]   A possible attenuation of stress-induced increases in striatal dopamine metabolism by the expression of non-functional masticatory activity in the rat [J].
Gómez, FM ;
Giralt, MT ;
Sainz, B ;
Arrúe, A ;
Prieto, M ;
García-Vallejo, P .
EUROPEAN JOURNAL OF ORAL SCIENCES, 1999, 107 (06) :461-467
[7]   EFFECT OF INHIBITION OF NITRIC-OXIDE SYNTHESIS ON VASOPRESSIN SECRETION IN CONSCIOUS RABBITS [J].
GOYER, M ;
BUI, H ;
CHOU, L ;
EVANS, J ;
KEIL, LC ;
REID, IA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (02) :H822-H828
[8]   INFLUENCE OF THYROID STATES ON STRESS GASTRIC-ULCER FORMATION [J].
HERNANDEZ, DE ;
WALKER, CH ;
MASON, GA .
LIFE SCIENCES, 1988, 42 (18) :1757-1764
[9]   Biting suppresses stress-induced expression of corticotropin-releasing factor (CRF) in the rat hypothalamus [J].
Hori, N ;
Yuyama, N ;
Tamura, K .
JOURNAL OF DENTAL RESEARCH, 2004, 83 (02) :124-128
[10]   Developmental regulation of nitric oxide synthase expression in rat skeletal bone [J].
Hukkanen, MVJ ;
Platts, LAM ;
De Marticorena, IF ;
O'Shaughnessy, M ;
MacIntyre, I ;
Polak, JM .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (06) :868-877
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