Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

被引：46

作者：

Moskalev, Alexey ^{[1
]}

Shaposhnikov, Mikhail ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biol, Komi Sci Ctr, Ural Branch, Syktyvkar, Russia

来源：

AGING-US | 2011年 / 3卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

Drosophila melanogaster; NF-kappa B; aging; lifespan; anti-aging agents; EXPRESSION; INFLAMMATION; PATTERNS; CELLS;

D O I：

10.18632/aging.100314

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is associated with NF-kappa B-dependent pro-inflammation. Here we demonstrated that inhibition of NF-kappa B with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

引用

收藏

页码：391 / 394

页数：4

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