Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

被引：45
作者：
Moskalev, Alexey [1 ]
Shaposhnikov, Mikhail [1 ]
机构：
[1] Russian Acad Sci, Inst Biol, Komi Sci Ctr, Ural Branch, Syktyvkar, Russia
来源：
AGING-US | 2011年 / 3卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
Drosophila melanogaster; NF-kappa B; aging; lifespan; anti-aging agents; EXPRESSION; INFLAMMATION; PATTERNS; CELLS;
D O I：
10.18632/aging.100314
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging is associated with NF-kappa B-dependent pro-inflammation. Here we demonstrated that inhibition of NF-kappa B with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
引用
收藏
页码：391 / 394
页数：4
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