Molecular Responses in Osteogenic Differentiation of Mesenchymal Stem Cells Induced by Physical Stimulation

被引：0

作者：

Togloom, Ariunaa ^{[1
,2
]}

Lim, Ki-Taek ^{[1
,2
]}

Kim, Jang-Ho ^{[1
,2
]}

Seonwoo, Hoon ^{[1
]}

Garg, Pankaj ^{[1
]}

Choung, Pill-Hoon ^{[4
,5
,6
]}

Cho, Chong-Su ^{[2
]}

Choung, Yun-Hoon ^{[3
]}

Chung, Jong Hoon ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Agr & Life Sci, Dept Biosyst & Biomat Sci & Engn, Seoul 151921, South Korea

[2] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151921, South Korea

[3] Ajou Univ, Sch Med, Dept Otolaryngol, Suwon 443721, South Korea

[4] Seoul Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul, South Korea

[5] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul, South Korea

[6] Seoul Natl Univ, Sch Dent, Tooth Bioengn Natl Res Lab Post BK21, Seoul 151921, South Korea

来源：

TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2011年 / 8卷 / 03期

关键词：

physical stimulation; mechanotransduction; signal transduction; gene expression; osteogenic differentiation; FLUID SHEAR-STRESS; NITRIC-OXIDE SYNTHASE; OSTEOBLAST-LIKE CELLS; ACTIVATED PROTEIN-KINASE; MARROW STROMAL CELLS; BONE-MARROW; MECHANICAL STIMULATION; EXTRACELLULAR-MATRIX; SIGNALING PATHWAYS; ACTIN CYTOSKELETON;

D O I：

暂无

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) have been recognized as a great source of stem cells in the field of regenerative medicine and regulation of MSCs such as differentiation into specific cells. Particular interest is the use of physical stimulation for the expression of the osteoblast-specific genes from MSCs for bone tissue regeneration. The mechanical forces on MSCs, such as fluid flow, enhance the mineralized matrix and specific gene expressions. This process called mechanotransduction comprises of the steps of mechanoreception, biochemical coupling, transmission of signal and effector cell response. Physical stimuli effectively regulate extracellular and intracellular signaling pathways to enhance the expression of specific transcription factors, and the release of osteocytes, ultimately expedite the production of active osteoblasts. Thus understating, identification and functional characterization of the mechanotransduction underlying the physical stimulation of MSCs is a critical issue for devising new bone regenerative treatments for bone-related diseases. In this review, we focus on the molecular mechanism responsible for the mechanotransduction of osteogenic differentiation of MSCs induced by physical stimulation.

引用

页码：271 / 281

页数：11