Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

被引：513

作者：

Isidro, Joana ^{[1
]}

Borges, Vitor ^{[1
]}

Pinto, Miguel ^{[1
]}

Sobral, Daniel ^{[1
]}

Santos, Joao Dourado ^{[1
]}

Nunes, Alexandra ^{[1
]}

Mixao, Veronica ^{[1
]}

Ferreira, Rita ^{[1
]}

Santos, Daniela ^{[2
]}

Duarte, Silvia ^{[2
]}

Vieira, Luis ^{[2
]}

Borrego, Maria Jose ^{[3
]}

Nuncio, Sofia ^{[4
]}

de Carvalho, Isabel Lopes ^{[4
]}

Pelerito, Ana ^{[4
]}

Cordeiro, Rita ^{[4
]}

Gomes, Joao Paulo ^{[1
,5
]}

机构：

[1] Natl Inst Hlth Doutor Ricardo Jorge INSA, Dept Infect Dis, Genom & Bioinformat Unit, Lisbon, Portugal

[2] Natl Inst Hlth Doutor Ricardo Jorge INSA, Dept Human Genet, Technol & Innovat Unit, Lisbon, Portugal

[3] Natl Inst Hlth Doutor Ricardo Jorge INSA, Dept Infect Dis, Natl Reference Lab Sexually Transmitted Infect, Lisbon, Portugal

[4] Natl Inst Hlth Doutor Ricardo Jorge INSA, Dept Infect Dis, Emergency Response & Biopreparedness Unit, Lisbon, Portugal

[5] Lusofona Univ, Fac Vet Med, Lisbon, Portugal

来源：

NATURE MEDICINE | 2022年 / 28卷 / 08期

基金：

欧盟地平线“2020”;

关键词：

VACCINIA VIRUS; DNA;

D O I：

10.1038/s41591-022-01907-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 2022 (refs. (1-6)). In this study, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with 2018-2019 cases linked to an endemic country, it segregates in a divergent phylogenetic branch, likely reflecting continuous accelerated evolution. An in-depth mutational analysis suggests the action of host APOBEC3 in viral evolution as well as signs of potential MPXV human adaptation in ongoing microevolution. Our findings also indicate that genome sequencing may provide resolution to track the spread and transmission of this presumably slow-evolving double-stranded DNA virus.

引用

页码：1569 / 1572

页数：4

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