Metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with azobisisobutyronitrile

被引：8

作者：

Zhao, Mengfei ^{[1
]}

Qin, Zengxin ^{[1
]}

Zhang, Kaixin ^{[1
]}

Li, Jizhen ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Dept Organ Chem, 2519 Jiefang Rd, Changchun 130021, Peoples R China

来源：

RSC ADVANCES | 2021年 / 11卷 / 49期

基金：

中国国家自然科学基金;

关键词：

BOND FUNCTIONALIZATION; GREEN CHEMISTRY; TRIFLUOROMETHYLATION; 8-ACYLAMINOQUINOLINES; BENZYLATION; TAFENOQUINE; IODINATION; QUINOLINES; AMINATION;

D O I：

10.1039/d1ra06013a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using K2S2O8, an efficient and metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with AIBN (azobisisobutyronitrile) was developed. Without any catalyst, various substrates and functional groups were compatible to afford corresponding products in moderate to high yields. A mechanism study displayed that a radical-radical coupling process was involved via the N-centered radical generation and delocalization of aryl amides.

引用

页码：30719 / 30724

页数：6

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