Effect of Vitamin D Supplementation on Serum Lipid Profiles in Children and Adolescence: A Meta-analysis

被引:1
作者
Amiri, Bita [1 ]
Namakin, Kokab [2 ]
Soltani, Maryam [3 ]
Shetty, Sameep [4 ,5 ]
Riahi, Seyed Mohammad [6 ]
机构
[1] Birjand Univ Med Sci, Dept Pediat, Sch Med, Birjand, Iran
[2] Birjand Univ Med Sci, Dept Pediat, Sch Med, Cardivasc Dis Res Ctr, Birjand, Iran
[3] Birjand Univ Med Sci, Razi Clin Res Dev Unit RCRDU, Birjand, Iran
[4] Manipal Coll Dent Sci, Dept Oral & Maxillofacial Surg, Mangalore, India
[5] Manipal Acad Higher Educ MAHE, Manipal, India
[6] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Dept Epidemiol & Biostat, Sch Med, Birjand, Iran
关键词
Vitamin D; Lipids; Child; Adolescent; CARDIOVASCULAR RISK-FACTORS; 25-HYDROXYVITAMIN D; ASSOCIATION; HEALTH; ATHEROSCLEROSIS; IMPROVEMENT; PREVALENCE; CHILDHOOD; DISEASE;
D O I
10.32598/jpr.10.1.987.1
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Vitamin D deficiency is an important risk factor for some chronic diseases. Some reports suggested that there is an interrelationship between lipids and cholecalciferol. Objectives: This meta-analysis was conducted to summarize the existing evidence of randomized controlled trials (RCTs) to evaluate the effect of vitamin D supplementation on lipid profiles in children and adolescents. Methods: In this systematic review and meta-analysis, databases, such as Web of Science, PubMed, Scopus, Google Scholar, EMBASE, ScienceDirect, Magiran, and SID were searched for studies up to December 21, 2019. This study was conducted according to PRISMA guidelines. I-square was used to measure the existing heterogeneity through included articles. Considering heterogeneity among articles, random-effect models were applied to pool Standardized Mean Differences (SMD) as overall effect size. Study eligibility criteria included children and adolescents (<18 years) and evaluation of the association between vitamin D and lipid profile. A P<0.05 was considered statistically significant and the analyses were conducted by STATA 14.0. Results: A total of 13 trials (number of participant=173) were included in the current metaanalysis. The SMD was 0.23, the vitamin D supplementation was associated with a significant slight increase in high-density lipoproteins (HDL) levels in children and adolescents (SMD 0.23; 95% CI, 0.02, 0.45, P=0.036; I2=57.7%, Egger's P=0.554). We found no significant association between vitamin D supplementation and LDL-cholesterol (SMD -0.10; 95% CI, -0.29, 0.09, P=0.310; I2=0.0%, Egger's P=0.689), total cholesterol (SMD -0.01; 95% CI, -0.20, 0.18, P=0.926; I2=0.0%, Egger's P=0.005), and triglycerides (SMD -0.10; 95% CI, 0.22, 0.02, P=0.093; I2=0.0%, Egger's P=0.160) levels. Conclusions: Vitamin D can marginally increase HDL levels, without any significant effect on LDL-C, TG, and TC levels.
引用
收藏
页码:1 / 15
页数:15
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