Nocodazole-induced changes in microtubule dynamics impair the morphology and directionality of migrating medial ganglionic eminence cells
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作者:
Baudoin, Jean-Pierre
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Hop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Univ Paris 06, Paris, FranceHop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Baudoin, Jean-Pierre
[1
,2
]
Alvarez, Chantal
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Hop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Univ Paris 06, Paris, FranceHop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Alvarez, Chantal
[1
,2
]
Gaspar, Patricia
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Hop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Univ Paris 06, Paris, FranceHop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Gaspar, Patricia
[1
,2
]
Metin, Christine
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Hop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Univ Paris 06, Paris, FranceHop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
Metin, Christine
[1
,2
]
机构:
[1] Hop La Pitie Salpetriere, INSERM U839, FR-75651 Paris 13, France
We have shown previously that actomyosin contractility plays an important role in controlling nuclear movements in future interneurons born in the medial ganglionic eminence (MGE) [ Bellion et al.: J Neurosci 2005; 25: 5691-5699]. Because microtubules are known to control the structural and motile properties of migrating neurons, we asked whether alterations in the dynamic instability of microtubules would impair MGE cell migration. Migration was analyzed in flat cocultures in which green-fluorescent-protein-expressing MGE cells migrate on cortical cells from their explant of origin. A low ( 100 nM) concentration of nocodazole shortened the leading process of MGE cells that nevertheless continued to migrate at the same rate but frequently changed their direction of migration relative to control cells. MGE cells treated with a higher ( 1 mu M) concentration of nocodazole that strongly destabilized microtubules took on multipolar morphology. They extended thin and labile processes. MGE cells no longer exhibited directional migration and migration velocity slowed 2-fold. These results suggest that microtubule stability is crucial for maintaining polarity and controlling the directional migration of MGE cells, whereas additional mechanisms are required to control cell motility. Copyright (c) 2008 S. Karger AG, Basel.
机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Gleeson, JG
Lin, PT
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机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Lin, PT
Flanagan, LA
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机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Flanagan, LA
Walsh, CA
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Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USAHarvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Gleeson, JG
Allen, KM
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Allen, KM
Fox, JW
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Fox, JW
Lamperti, ED
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Lamperti, ED
Berkovic, S
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Berkovic, S
Scheffer, I
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Scheffer, I
Cooper, EC
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Cooper, EC
Dobyns, WB
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Dobyns, WB
Minnerath, SR
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Minnerath, SR
Ross, ME
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Ross, ME
Walsh, CA
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机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Gleeson, JG
Lin, PT
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机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Lin, PT
Flanagan, LA
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机构:Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
Flanagan, LA
Walsh, CA
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机构:
Harvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USAHarvard Univ, Dept Neurol, Div Neurogenet, Beth Israel Deaconess Med Ctr,Inst Med, Boston, MA 02115 USA
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Gleeson, JG
Allen, KM
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h-index: 0
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Allen, KM
Fox, JW
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Fox, JW
Lamperti, ED
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h-index: 0
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Lamperti, ED
Berkovic, S
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Berkovic, S
Scheffer, I
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Scheffer, I
Cooper, EC
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Cooper, EC
Dobyns, WB
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机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Dobyns, WB
Minnerath, SR
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h-index: 0
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Minnerath, SR
Ross, ME
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h-index: 0
机构:Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA
Ross, ME
Walsh, CA
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机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Div Neurogenet, Boston, MA 02115 USA