Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin

被引：806

作者：

Viard, I

Wehrli, P

Bullani, R

Schneider, P

Holler, N

Salomon, D

Hunziker, T

Saurat, JH

Tschopp, J

French, LE ^{[1
]}

机构：

[1] Univ Geneva, Sch Med, Dept Dermatol, CH-1211 Geneva 4, Switzerland

[2] Univ Lausanne, BIL Res Ctr, Inst Biochem, CH-1066 Epalinges, Switzerland

[3] Univ Bern, Sch Med, Dept Dermatol, CH-3010 Bern, Switzerland

来源：

SCIENCE | 1998年 / 282卷 / 5388期

关键词：

D O I：

10.1126/science.282.5388.490

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and Large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found ro express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.

引用

页码：490 / 493

页数：4

共 34 条

[1] Intravenous immune globulin affects cytokine production in T lymphocytes and monocytes macrophages [J].