Current Status of HbA1c Biosensors

被引：36

作者：

Lin, Hua ^{[1
]}

Yi, Jun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

SENSORS | 2017年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

glycated hemoglobin (HbA1c); biosensor; boronic acid; antibody; fructosyl valine; GLYCATED HEMOGLOBIN HBA(1C); ENZYME SENSOR; IMPEDANCE MEASUREMENT; FRUCTOSYL VALINE; RECENT PROGRESS; FLOW-INJECTION; BLOOD-GLUCOSE; ACID-BINDING; SINGLE-USE; THIN-FILM;

D O I：

10.3390/s17081798

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the alpha-amino group of beta Val1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements.

引用

页数：18

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