Casein kinase 1: Complexity in the family

被引：198

作者：

Cheong, Jit Kong ^{[1
]}

Virshup, David M. ^{[1
]}

机构：

[1] Duke NUS Grad Med Sch, Canc & Stem Cell Biol Program, Singapore 169857, Singapore

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 04期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

Casein kinase 1; Kinase; Phosphorylation; Wnt signaling; Circadian rhythms; IN-VITRO; PHOSPHORYLATION; INHIBITION; WNT; ACTIVATION; CK1-DELTA; DELTA; CKI;

D O I：

10.1016/j.biocel.2010.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CK1 family of serine/threonine kinases regulates diverse cellular processes, through binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates primed by prior phosphorylation, and works closely with other kinases in the Wnt pathway. CK1 is itself regulated by posttranslational modification, including autophosphorylation. We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：465 / 469

页数：5

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