Levels of serum-soluble receptor for interleukin-2 in patients with colorectal cancer

被引：6

作者：

Saito, H ^{[1
]}

Tsujitani, S ^{[1
]}

Katano, K ^{[1
]}

Ikeguchi, M ^{[1
]}

Maeta, M ^{[1
]}

Kaibara, N ^{[1
]}

机构：

[1] Tottori Univ, Sch Med, Dept Surg 1, Yonago, Tottori 683, Japan

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1998年 / 28卷 / 10期

关键词：

interleukin-2; receptor; colorectal cancer;

D O I：

10.1007/BF02483977

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P < 0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (<531 U/ml) was significantly better than that of those with high levels (P < 0.05), These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.

引用

页码：1115 / 1117

页数：3

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