Levels of serum-soluble receptor for interleukin-2 in patients with colorectal cancer

被引：6
|
作者：
Saito, H [1 ]
Tsujitani, S [1 ]
Katano, K [1 ]
Ikeguchi, M [1 ]
Maeta, M [1 ]
Kaibara, N [1 ]
机构：
[1] Tottori Univ, Sch Med, Dept Surg 1, Yonago, Tottori 683, Japan
来源：
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1998年 / 28卷 / 10期
关键词：
interleukin-2; receptor; colorectal cancer;
D O I：
10.1007/BF02483977
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P < 0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (<531 U/ml) was significantly better than that of those with high levels (P < 0.05), These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.
引用
收藏
页码：1115 / 1117
页数：3
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