Evolution of a Strategy for the Enantioselective Synthesis of (-)-Cajanusine

被引：17

作者：

Guo, Renyu ^{[1
]}

Witherspoon, Brittany P. ^{[1
]}

Brown, M. Kevin ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 11期

关键词：

N-HYDROXYPHTHALIMIDE ESTERS; OXIDATION; SKELETON;

D O I：

10.1021/jacs.0c00359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first enantioselective synthesis of (-)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.

引用

页码：5002 / 5006

页数：5

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