Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies

被引：41

作者：

Zolochevska, Olga ^{[1
]}

Taglialatela, Giulio ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Neurol, Mitchell Ctr Neurodegenerat Dis, Galveston, TX 77555 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 26期

关键词：

Alzheimer's disease; Non-Demented with Alzheimer's Neuropathology; compensatory mechanisms in AD; resistance to cognitive decline; NORMAL OLDER-ADULTS; APOE RECEPTOR 2; AMYLOID DEPOSITION; OXIDATIVE STRESS; BETA OLIGOMERS; ACCELERATED DECLINE; NEUROTROPHIC FACTOR; INTRANASAL INSULIN; RESERVE HYPOTHESIS; BRAIN RESERVE;

D O I：

10.2174/1381612822666160518142110

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease (AD) is a terminal neurodegenerative disorder that is characterized by accumulation of amyloid plaques and neurofibrillary tangles in the central nervous system. However, certain individuals remain cognitively intact despite manifestation of substantial plaques and tangles consistent with what would be normally associated with fully symptomatic AD. Mechanisms that allow these subjects to escape dementia remain unresolved and understanding such protective biological processes could reveal novel targets for the development of effective treatments for AD. In this review article we discuss potential compensatory mechanisms that allow these individuals to remain cognitively intact despite the typical AD neuropathology.

引用

页码：4063 / 4068

页数：6

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