Targeting apoptotic and autophagic pathways for cancer therapeutics

被引：142

作者：

Liu, Jun-jie ^{[1
]}

Lin, Mou ^{[1
]}

Yu, Jia-ying ^{[1
]}

Liu, Bo ^{[1
]}

Bao, Jin-ku ^{[1
]}

机构：

[1] Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China

来源：

CANCER LETTERS | 2011年 / 300卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Cancer; Apoptosis; Autophagy; Pathways; NF-KAPPA-B; SIGNAL-REGULATED KINASE; BCL-2 FAMILY PROTEINS; CELL-DEATH; MITOCHONDRIAL PERMEABILITY; MOLECULAR-MECHANISMS; MEDIATED APOPTOSIS; CONCANAVALIN-A; X-L; P53;

D O I：

10.1016/j.canlet.2010.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apoptosis and autophagy are genetically regulated evolutionarily-conserved processes that regulate cell fate however apoptosis invariably contributes to cancer cell death whereas autophagy plays the Janus role of cancer cell survival and death In this review we firstly focus on targeting cancer cells via several key apoptotic pathways for anti-cancer therapy Additionally we demonstrate that some autophagic pathways play dual roles in cancer and further elucidate the intricate relationship between apoptosis and autophagy In summary these findings may ultimately allow biologists to harness apoptotic and autophagic pathways as novel targets for cancer therapeutics (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：105 / 114

页数：10

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