Neural control of immune cell trafficking

被引：38

作者：

Mueller, Scott N. ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Australia

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2022年 / 219卷 / 03期

基金：

英国医学研究理事会;

关键词：

PRIMATE LYMPH-NODES; T-CELL; NERVOUS-SYSTEM; SYMPATHETIC INNERVATION; SENSORY NEURONS; INDUCED REDISTRIBUTION; RECEPTOR STIMULATION; B-LYMPHOCYTES; NAIVE CD4(+); TUMOR-GROWTH;

D O I：

10.1084/jem.20211604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-talk between the nervous system and the immune system is important in normal physiology and disease. This review discusses how neural signals regulate leukocyte migration around the body and within tissues and contributions by diverse neural signals to effective immune responses. Leukocyte trafficking between blood and tissues is an essential function of the immune system that facilitates humoral and cellular immune responses. Within tissues, leukocytes perform surveillance and effector functions via cell motility and migration toward sites of tissue damage, infection, or inflammation. Neurotransmitters that are produced by the nervous system influence leukocyte trafficking around the body and the interstitial migration of immune cells in tissues. Neural regulation of leukocyte dynamics is influenced by circadian rhythms and altered by stress and disease. This review examines current knowledge of neuro-immune interactions that regulate leukocyte migration and consequences for protective immunity against infections and cancer.

引用

页数：12

共 117 条

[1] Neural reflexes in inflammation and immunity [J].

Andersson, Ulf ;

Tracey, Kevin J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (06) :1057-1068

[2] A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions [J].

Bachmann, Samia B. ;

Gsponer, Denise ;

Montoya-Zegarra, Javier A. ;

Schneider, Martin ;

Scholkmann, Felix ;

Tacconi, Carlotta ;

Noerrelykke, Simon F. ;

Proulx, Steven T. ;

Detmar, Michael .

CELL REPORTS, 2019, 27 (11) :3305-+

[3] Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia [J].

Baral, Pankaj ;

Umans, Benjamin D. ;

Li, Lu ;

Wallrapp, Antonia ;

Bist, Meghna ;

Kirschbaum, Talia ;

Wei, Yibing ;

Zhou, Yan ;

Kuchroo, Vijay K. ;

Burkett, Patrick R. ;

Yipp, Bryan G. ;

Liberles, Stephen D. ;

Chiu, Isaac M. .

NATURE MEDICINE, 2018, 24 (04) :417-+

[4] Catecholamine-induced leukocytosis: Early observations, current research, and future directions [J].

Benschop, RJ ;

RodriguezFeuerhahn, M ;

Schedlowski, M .

BRAIN BEHAVIOR AND IMMUNITY, 1996, 10 (02) :77-91

[5] Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans [J].

Besedovsky, Luciana ;

Linz, Barbara ;

Dimitrov, Stoyan ;

Groch, Sabine ;

Born, Jan ;

Lange, Tanja .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2014, 306 (11) :E1322-E1329

[6] Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4 [J].

Besedovsky, Luciana ;

Born, Jan ;

Lange, Tanja .

FASEB JOURNAL, 2014, 28 (01) :67-75

[7] Immune regulation by glucocorticoids [J].

Cain, Derek W. ;

Cidlowski, John A. .

NATURE REVIEWS IMMUNOLOGY, 2017, 17 (04) :233-247

[8] Sympathetic nerve distribution in human lymph nodes [J].

Cleypool, Cindy G. J. ;

Mackaaij, Claire ;

Lotgerink Bruinenberg, Dyonne ;

Schurink, Bernadette ;

Bleys, Ronald L. A. W. .

JOURNAL OF ANATOMY, 2021, 239 (02) :282-289

[9] Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity [J].

Cohen, Jonathan A. ;

Edwards, Tara N. ;

Liu, Andrew W. ;

Hirai, Toshiro ;

Jones, Marsha Ritter ;

Wu, Jianing ;

Li, Yao ;

Zhang, Shiqun ;

Ho, Jonhan ;

Davis, Brian M. ;

Albers, Kathryn M. ;

Kaplan, Daniel H. .

CELL, 2019, 178 (04) :919-+

[10] Choline acetyltransferase-expressing T cells are required to control chronic viral infection [J].

Cox, Maureen A. ;

Duncan, Gordon S. ;

Lin, Gloria H. Y. ;

Steinberg, Benjamin E. ;

Yu, Lisa X. ;

Brenner, Dirk ;

Buckler, Luke N. ;

Elia, Andrew J. ;

Wakeham, Andrew C. ;

Nieman, Brian ;

Dominguez-Brauer, Carmen ;

Elford, Alisha R. ;

Gill, Kyle T. ;

Kubli, Shawn P. ;

Haight, Jillian ;

Berger, Thorsten ;

Ohashi, Pamela S. ;

Tracey, Kevin J. ;

Olofsson, Peder S. ;

Mak, Tak W. .

SCIENCE, 2019, 363 (6427) :639-+

← 1 2 3 4 5 6 7 8 9 10 →