Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family

被引：85
作者：
Hyndman, DJ [1 ]
Flynn, TG [1 ]
机构：
[1] Queens Univ, Dept Biochem, Kingston, ON K7L 3N6, Canada
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1399卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
aldo-keto reductase; adrenal gland; sequence; tissue distribution; RACE-PCR;
D O I：
10.1016/S0167-4781(98)00109-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have isolated a human cDNA clone from small intestine that represents a new member of the aldo-keto reductase family. This new member showed 70% identity at the protein level to human aldose reductase and around 80% identity to other Chinese hamster and mouse reductases. The expression pattern shows that this message is located primarily in the adrenal gland, thus suggesting an involvement in steroid metabolism. It is also strongly expressed in the intestinal tract and has been called human small intestine reductase. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：198 / 202
页数：5
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