Pharmacogenomics of the RNA World: Structural RNA Polymorphisms in Drug Therapy

被引：49

作者：

Sadee, W. ^{[1
]}

Wang, D. ^{[1
]}

Papp, A. C. ^{[1
]}

Pinsonneault, J. K. ^{[1
]}

Smith, R. M. ^{[1
]}

Moyer, R. A. ^{[1
]}

Johnson, A. D. ^{[2
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Pharmacol, Program Pharmacogenom, Columbus, OH 43210 USA

[2] NHLBI, Framingham Heart Study, Framingham, MA USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 03期

关键词：

ALLELIC EXPRESSION IMBALANCE; OPIOID RECEPTOR GENE; GENOME-WIDE ANALYSIS; MESSENGER-RNA; HUMAN BRAIN; HUMAN PONS; ASSOCIATION; VARIANTS; EVENTS; CELLS;

D O I：

10.1038/clpt.2010.314

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of pharmacogenomic biomarkers can enhance treatment outcomes. Regulatory polymorphisms are promising biomarkers that have proven difficult to uncover. They come in two flavors: those that affect transcription (regulatory single-nucleotide polymorphisms (rSNPs)) and those that affect RNA functions such as splicing, turnover, and translation (termed structural RNA SNPs (srSNPs)). This review focuses on the role of srSNPs in drug metabolism, transport, and response. An understanding of the nature and diversity of srSNPs and rSNPs enables clinical scientists to evaluate genetic biomarkers.

引用

页码：355 / 365

页数：11

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