Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus

被引：97

作者：

Eyileten, Ceren ^{[1
]}

Kaplon-Cieslicka, Agnieszka ^{[2
]}

Mirowska-Guzel, Dagmara ^{[1
]}

Malek, Lukasz ^{[3
]}

Postula, Marek ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Expt & Clin Pharmacol, Ctr Preclin Res & Technol CEPT, Warsaw, Poland

[2] Med Univ Warsaw, Dept Cardiol, Warsaw, Poland

[3] Univ Phys Educ, Fac Rehabil, Warsaw, Poland

来源：

JOURNAL OF DIABETES RESEARCH | 2017年 / 2017卷

关键词：

SOLUBLE P-SELECTIN; ACTIVATED PROTEIN-KINASE; FACTOR BDNF; METABOLIC SYNDROME; HUMAN PLATELETS; GLUCOSE-METABOLISM; CHINESE PATIENTS; TRKB RECEPTORS; ENERGY-BALANCE; SEVERE OBESITY;

D O I：

10.1155/2017/2823671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.

引用

页数：14

共 146 条

[1] Progesterone reverses 17β-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices [J].