Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles

被引：22

作者：

Dermyer, Michael R.

Ding, Qizhu

Huband, Michael D.

Jiao, Wenhua

Kaneko, Takushi

Khlebnikov, Vladimir

Kirn, Ji-Young

Lall, Manjinder S.

Maiti, Samarendra N.

Romero, Karina

Wu, Xiujuan

机构：

[1] Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA

[2] Pfizer Global Res & Dev, Groton, CT 06340 USA

[3] Naeja Pharmaceut Inc, Edmonton, AB T6E 5V2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 16期

关键词：

oxazolidinones; conformationally-restricted; gram-positive activity; fastidious gram-negative activity;

D O I：

10.1016/j.bmcl.2007.05.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of conformationally-restricted oxazolidinones was synthesized which possess a fused pyrazole ring substituted with various alkyl, aryl and heteroaryl substituents. A number of analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4694 / 4698

页数：5

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