Aberrant cytoplasmic localization of N-CoR in colorectal tumors

被引：33

作者：

Fernandez-Majada, Vanessa

Pujadas, Jaume

Vilardell, Felip

Capella, Gabriel

Mayo, Marty W.

Bigas, Anna

Espinosa, Lluis

机构：

[1] Inst Biomed Bellvitge, E-08907 Barcelona, Spain

[2] Inst Invest Biomed Bellvitge, Ctr Mol Oncol, Barcelona, Spain

[3] Inst Invest Biomed Bellvitge, Inst Catala Oncol, Lab Recerca Translac, Barcelona, Spain

[4] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA

来源：

CELL CYCLE | 2007年 / 6卷 / 14期

关键词：

N-CoR; IKK; 14-3-3; colorectal cancer; cytoplasmic export;

D O I：

10.4161/cc.6.14.4429

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have previously shown that IKKs are aberrantly activated in colon cancer cells leading to SMRT phosphorylation and its release from the chromatin. We now show that IKK alpha phosphorylates the homologous N-CoR corepressor in serines 2345 and 2348 creating a functional 14-3-3 binding domain ( RKpS2348KSP). Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors.

引用

收藏

页码：1748 / 1752

页数：5

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