Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway

被引：46
作者：
Kitsis, Richard N. [1 ,2 ]
Molkentin, Jeffery D. [3 ,4 ,5 ]
机构：
[1] Albert Einstein Coll Med, Dept Med, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Cell Biol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp Med Ctr, Howard Hughes Med Inst, Cincinnati, OH 45229 USA
[5] Univ Cincinnati, Dept Pediat, Cincinnati, OH 45229 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 20期
关键词：
ENDOPLASMIC-RETICULUM; PERMEABILITY TRANSITION; CYCLOPHILIN-D; PROAPOPTOTIC BAX; CA2+; RIP;
D O I：
10.1073/pnas.1003827107
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：9031 / 9032
页数：2
相关论文
共 17 条
[11]   Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum [J].
Oakes, SA ;
Scorrano, L ;
Opferman, JT ;
Bassik, MC ;
Nishino, M ;
Pozzan, T ;
Korsmeyer, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (01) :105-110
[12]   Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics [J].
Pizzo, Paola ;
Pozzan, Tullio .
TRENDS IN CELL BIOLOGY, 2007, 17 (10) :511-517
[13]   Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia [J].
Schinzel, AC ;
Takeuchi, O ;
Huang, ZH ;
Fisher, JK ;
Zhou, ZP ;
Rubens, J ;
Hetz, C ;
Danial, NN ;
Moskowitz, MA ;
Korsmeyer, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (34) :12005-12010
[14]   BAX and BAK regulation of endoplasmic reticulum Ca2+:: A control point for apoptosis [J].
Scorrano, L ;
Oakes, SA ;
Opferman, JT ;
Cheng, EH ;
Sorcinelli, MD ;
Pozzan, T ;
Korsmeyer, SJ .
SCIENCE, 2003, 300 (5616) :135-139
[15]   Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways [J].
Timmins, Jenelle M. ;
Ozcan, Lale ;
Seimon, Tracie A. ;
Li, Gang ;
Malagelada, Cristina ;
Backs, Johannes ;
Backs, Thea ;
Bassel-Duby, Rhonda ;
Olson, Eric N. ;
Anderson, Mark E. ;
Tabas, Ira .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (10) :2925-2941
[16]   Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death [J].
Wei, MC ;
Zong, WX ;
Cheng, EHY ;
Lindsten, T ;
Panoutsakopoulou, V ;
Ross, AJ ;
Roth, KA ;
MacCregor, GR ;
Thompson, CB ;
Korsmeyer, SJ .
SCIENCE, 2001, 292 (5517) :727-730
[17]   Necrotic cell death in C-elegans requires the function of calreticulin and regulators of Ca2+ release from the endoplasmic reticulum [J].
Xu, KL ;
Tavernarakis, N ;
Driscoll, M .
NEURON, 2001, 31 (06) :957-971
12