Hollow mesoporous silica nanoparticles conjugated with pH-sensitive amphiphilic diblock polymer for controlled drug release

被引：64

作者：

Mei, Xiao ^{[1
]}

Chen, Dongyun ^{[1
]}

Li, Najun ^{[1
]}

Xu, Qingfeng ^{[1
]}

Ge, Jianfeng ^{[1
]}

Li, Hua ^{[1
]}

Lu, Jianmei ^{[1
]}

机构：

[1] Soochow Univ, Lab Absorbent Mat & Tech Environm, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2012年 / 152卷

基金：

中国国家自然科学基金;

关键词：

Hollow mesoporous silica nanoparticles; Atom transfer radical polymerization; pH-sensitive; Controlled drug release; DELIVERY; MCM-41; TRANSFECTION; FABRICATION; PARTICLES; MICELLES; STORAGE; SPHERES; ACID;

D O I：

10.1016/j.micromeso.2011.12.015

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A pH-sensitive amphiphilic diblock polymer (poly(PDM-b-PEGMA)) was grafted from the surface of hollow mesoporous silica nanoparticles (HMS) via atom transfer radical polymerization (ATRP). The morphology of the obtained core-shell nanocomposites, HMS@poly(PDM-b-PEGMA), was determined by transmission electron microscopy (TEM) and scanning electron microscope (SEM). The nanocomposites could be used as drug carriers due to the excellent biocompatibility with a high drug loading efficiency as 80%. Furthermore, less than 10 wt.% of DOX was released from the nanocomposites in neutral condition. When the solution is adjusted to acidic, more than 80 wt.% of DOX was released. In addition, in vitro experiments with human hepatoma 7402 cells and L02 lung cancer cells demonstrated that the nanocomposites could be internalized by both kinds of cells effectively but only release drug in cancer cells. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：16 / 24

页数：9

共 40 条

[1] Controlling the delivery kinetics from colloidal mesoporous silica nanoparticles with pH-sensitive gates [J].