Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy

被引：5

作者：

Barkhuizen, Melinda ^{[1
,2
,3
,10
]}

van Mechelen, Ralph ^{[1
,2
]}

Vermeer, Marijne ^{[1
,2
]}

Chedraui, Peter ^{[4
,5
]}

Paes, Dean ^{[2
]}

van den Hove, Daniel L. A. ^{[2
,6
]}

Vaes, Bart ^{[7
]}

Mays, Robert W. ^{[7
]}

Steinbusch, Harry W. M. ^{[2
]}

Robertson, Nicola J. ^{[8
]}

Kramer, Boris W. ^{[1
,2
,8
,9
]}

Gavilanes, Antonio W. D. ^{[1
,2
,4
,9
]}

机构：

[1] Maastricht Univ, Med Ctr MUMC, Dept Pediat, Maastricht, Netherlands

[2] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNs, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[3] North West Univ, DST NWU Preclin Drug Dev Platform, Potchefstroom, South Africa

[4] Univ Catolica Santiago Guayaquil, Inst Invest & Innovat SaludIntegral, Fac Ciencias Med, Guayaquil, Ecuador

[5] Univ Catolica Nuestra Senora Asuncion, Fac Ciencias Salud, Asuncion, Paraguay

[6] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[7] Athersys Inc, Dept Regenerat Med, Cleveland, OH USA

[8] UCL Inst Womens Hlth, London, England

[9] Maastricht Univ, Sch Oncol & Dev Biol, Maastricht, Netherlands

[10] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2019年 / 362卷

基金：

新加坡国家研究基金会;

关键词：

Hypoxic-ischemic encephalopathy; Preterm brain; Stem cell therapy; Neurodevelopment; MESENCHYMAL STEM-CELLS; BRAIN-INJURY; PERINATAL ASPHYXIA; DOUBLE-BLIND; MATURATION; EFFICACY; INFANTS; NEURONS; SAFETY; BORN;

D O I：

10.1016/j.bbr.2019.01.016

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects of multipotent adult progenitor cells (MAPC) on long-term behavioral outcomes in a preterm rat model of perinatal asphyxia. Rats of both sexes were treated with two doses of MAPCs within 24 h after the insult. Locomotor, cognitive and psychiatric impairments were evaluated starting at 1.5 (juvenile) and 6 months (adult). Hypoxia-ischemia affected locomotion, cognition, and anxiety in a sex-dependent manner, with higher vulnerability observed in males. The MAPC therapy partially attenuated deficits in object recognition memory in females of all tested ages, and in the adult males. The hypoxic insult caused delayed hyperactivity in adult males, which was corrected by MAPC therapy. These results suggest that MAPCs may have long-term benefits for neurodevelopmental outcome after preterm birth and global hypoxia-ischemia, which warrants further preclinical exploration.

引用

页码：77 / 81

页数：5

共 37 条

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