SIMULTANEOUS DETERMINATION OF L-DOPA AND BENSERAZIDE IN BINARY MIXTURES USING FIRST DERIVATIVE OF THE RATIO-VOLTAMMETRIC METHODS BASED ON THEIR OXIDATION ON SOLID ELECTRODE

The electrochemical behavior of L-dopa and benserazide at a solid electrode has been investigated using different voltammetric techniques. The anodic voltammetric characteristics of the selected compounds have been studied in aqueous media as a function of pH by cyclic, differential pulse and square wave voltammetric techniques. First derivative of the ratio voltammetric methods for determination of these compounds in their dosage forms in the presence of each other has been described. This technique depends on the measuring of the first derivative of ratio voltammograms of each concentration as a function of the increased concentrations. DP and SW voltammetric methods depend on the measuring of first derivative of the ratio voltammetry by measurements of the selected potentials corresponding to either maximums or minimums for both drugs. The linear response was within the range of 1 x 10(-5)-8 x 10(-5) and 1 x 10(-5)-2 x 10(-4) M for L-dopa and benserazide, respectively. The validity of the proposed methods was successfully assessed for analyses of both drugs in laboratory-prepared mixtures and in commercial tablet formulations. The proposed methods have successfully applied to the simultaneous determination of these compounds in the presence of each other.