A study in the relationships between leptin, insulin, and body fat in Asian subjects

被引:32
作者
Ho, SC [1 ]
Tai, ES [1 ]
Eng, PHK [1 ]
Ramli, A [1 ]
Tan, CE [1 ]
Fok, ACK [1 ]
机构
[1] Singapore Gen Hosp, Dept Endocrinol, Singapore 169608, Singapore
关键词
leptin; obesity; insulin resistance; lipid profile; body fat distribution;
D O I
10.1038/sj.ijo.0800801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: To study the relationship of leptin concentrations with indices of obesity, fasting insulin, insulin resistance and lipid profiles (total cholesterol, low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)- cholesterol and triglyceride) in an Asian cohort. DESIGN: Cross sectional study. SUBJECTS: A total of 133 healthy volunteers were enrolled (64 female: age: 25-61 y, body mass index (BMI): 18.7-45.1 kg/m(2) and 69 male: age: 25-61 y, BMI: 19.3-35.0 kg/m(2)). MEASUREMENTS: Weight, height, waist and hip circumferences, blood pressure, lean body mass (by bioelectric impedence analysis (BIA)), plasma leptin and lipid profiles were taken after a 10h fast, RESULTS: Percentage of body fat measured by bioelectric impedance was the strongest determinant of plasma leptin (r= 0.844, P < 0.0001). Females had higher leptin concentrations than males for the same fat mass. In a multiple linear regression model, body fat percentage, (percentage body fat gender), hip circumference and fasting insulin were significant determinants of leptin concentration (r = 0.882, P < 0.0001). CONCLUSION: Leptin concentration correlated closely with percentage body fat in Asian subjects. Hip circumference as a corollary for peripheral obesity, was better associated with leptin than waist circumference or waist-to-hip ratio (WHR). Distribution of fat in females tended to be peripheral and may partly explain the gender difference. Fasting insulin level and central obesity were correlated with HDL-cholesterol, triglyceride and blood pressure, while fasting leptin had little correlation with these metabolic parameters. Therefore, insulin resistance was a better guide to cardiovascular risk assessment than plasma leptin.
引用
收藏
页码:246 / 252
页数:7
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