Ionic liquid-based homogeneous liquid-liquid microextraction for the determination of antibiotics in milk by high-performance liquid chromatography

被引：77

作者：

Gao, Shiqian ^{[1
]}

Jin, Haiyan ^{[1
]}

You, Jingyan ^{[1
]}

Ding, Yi ^{[1
]}

Zhang, Nan ^{[1
]}

Wang, Ying ^{[1
]}

Ren, Ruibing ^{[1
]}

Zhang, Rui ^{[1
]}

Zhang, Hanqi ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY A | 2011年 / 1218卷 / 41期

关键词：

Ionic liquid-based homogeneous liquid-liquid microextraction (IL-based HLLME); Fluroquinolones; Sulfonamides; Milk samples; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; AQUEOUS 2-PHASE SYSTEMS; WATER SAMPLES; FLUORESCENCE DETECTION; WASTE-WATER; QUIONLONES RESIDUES; MUSCLE-TISSUES; BOVINE-MILK; TEMPERATURE;

D O I：

10.1016/j.chroma.2011.08.063

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ionic liquid-based homogeneous liquid-liquid microextraction (IL-based HLLME) high-performance liquid chromatography was developed and applied to the extraction, separation and determination of some antibiotics in milk. The proteins and lipids were removed by adding salt and adjusting the pH value. The homogeneous extraction was applied to the improvement of recoveries for IL phase and analytes. The experimental parameters of the IL-based HLLME, including salt concentration in sample solution, pH value of sample solution, volume of [C6MIM][BF4], amount of ion-pairing agent (NH4PF6), and extraction time, were evaluated. The limits of detection for enoxacin, pefloxacin, norfloxacin, enrofloxacin, sulfamethoxazole and sulfadimethoxine were 15.8, 7.07, 5.13, 4.00, 7.79 and 8.33 mu g L-1, respectively. When the proposed method was applied to the analysis of milk samples the recoveries of the analytes ranged from 92.5 to 118.6% and relative standard deviations were lower than 7.00%. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：7254 / 7263

页数：10

共 52 条

[1] A novel microextraction technique based on 1-hexylpyridinium hexafluorophosphate ionic liquid for the preconcentration of zinc in water and milk samples [J].

Abdolmohammad-Zadeh, H. ;

Sadeghi, G. H. .

ANALYTICA CHIMICA ACTA, 2009, 649 (02) :211-217

[2] Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry [J].

Aguilera-Luiz, M. M. ;

Martinez Vidal, Jose Luis ;

Romero-Gonzalez, Roberto ;

Garrido Frenich, Antonia .

JOURNAL OF CHROMATOGRAPHY A, 2008, 1205 (1-2) :10-16

[3]

[Anonymous], OFF J EUR UNION L, VL15, P1

[4]

[Anonymous], 2003, CHIN J VET DRUG, V37, P15

[5] Determination of pKa values of active pharmaceutical ingredients [J].

Babic, Sandra ;

Horvat, Alka J. M. ;

Pavlovic, Dragana Mutavdzic ;

Kastelan-Macan, Marija .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2007, 26 (11) :1043-1061

[6] In situ solvent formation microextraction based on ionic liquids: A novel sample preparation technique for determination of inorganic species in saline solutions [J].

Baghdadi, Majid ;

Shemirani, Farzaneh .

ANALYTICA CHIMICA ACTA, 2009, 634 (02) :186-191

[7] Retention behaviour of quinolone derivatives in high-performance liquid chromatography -: Effect of pH and evaluation of ionization constants [J].

Barbosa, J ;

Bergés, R ;

Nebot, VS .

JOURNAL OF CHROMATOGRAPHY A, 1998, 823 (1-2) :411-422

[8] Ionic liquids in separation techniques [J].

Berthod, A. ;

Ruiz-Angel, Mt ;

Carda-Broch, S. .

JOURNAL OF CHROMATOGRAPHY A, 2008, 1184 (1-2) :6-18

[9] A simple and rapid assay based on hot water extraction and liquid chromatography-tandem mass spectrometry for monitoring quinolone residues in bovine milk [J].

Bogialli, Sara ;

D'Ascenzo, Giuseppe ;

Di Corcia, Antonio ;

Lagana, Aldo ;

Nicolardi, Simone .

FOOD CHEMISTRY, 2008, 108 (01) :354-360

[10] Multi-method for the determination of antibiotics of different substance groups in milk and validation in accordance with Commission Decision 2002/657/EC [J].

Bohm, D. A. ;

Stachel, C. S. ;

Gowik, P. .

JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (46) :8217-8223

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