Primary biliary cholangitis: advances in understanding and management

被引：4

作者：

Smith, Alex ^{[1
]}

Giles, Benjamin ^{[1
]}

Aspinall, Richard J. ^{[1
]}

机构：

[1] Portsmouth Hosp Univ NHS Trust, Queen Alexandra Hosp, Portsmouth Liver Ctr, Portsmouth, Hants, England

来源：

BRITISH JOURNAL OF HOSPITAL MEDICINE | 2022年 / 83卷 / 03期

关键词：

Cholestasis; Cirrhosis; Fibrate; Obeticholic acid; Primary biliary cholangitis; Pruritus; Ursodeoxycholic acid; PLACEBO-CONTROLLED TRIAL; URSODEOXYCHOLIC ACID; OBETICHOLIC ACID; DOUBLE-BLIND; CIRRHOSIS; EFFICACY; PRURITUS; FENOFIBRATE; SERTRALINE; THERAPY;

D O I：

10.12968/hmed.2021.0450

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent years have seen major advances in our understanding of primary biliary cholangitis, with the condition now renamed to reflect the majority of patients who do not have cirrhosis. Data from large multicentre studies have greatly increased our knowledge of the natural history of primary biliary cholangitis, making the identification of higher risk patients clearer and facilitating the development of new medications. Recent guidelines have emphasised the importance of risk stratification, targeted treatment of symptoms and early prioritisation for second line therapies. The review summarises recent major developments in our understanding of primary biliary cholangitis and its management.

引用

页数：9

共 36 条

[1] PRIMARY BILIARY CIRRHOSIS [J].

AHRENS, EH ;

PAYNE, MA ;

KUNKEL, HG ;

EISENMENGER, WJ ;

BLONDHEIM, SH .

MEDICINE, 1950, 29 (04) :299-364

[2] Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis' [J].

Beuers, Ulrich ;

Gershwin, M. Eric ;

Gish, Robert G. ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lindor, Keith ;

Ma, Xiong ;

Mackay, Ian R. ;

Pares, Albert ;

Tanaka, Atsushi ;

Vierling, John M. ;

Poupon, Raoul .

JOURNAL OF HEPATOLOGY, 2015, 63 (05) :1285-1287

[3] Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis [J].

Browning, J ;

Combes, B ;

Mayo, MJ .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (12) :2736-2741

[4] The UK-PBC Risk Scores: Derivation and Validation of a Scoring System for Long-Term Prediction of End-Stage Liver Disease in Primary Biliary Cholangitis [J].

Carbone, Marco ;

Sharp, Stephen J. ;

Flack, Steve ;

Paximadas, Dimitrios ;

Spiess, Kelly ;

Adgey, Carolyn ;

Griffiths, Laura ;

Lim, Reyna ;

Trembling, Paul ;

Williamson, Kate ;

Wareham, Nick J. ;

Aldersley, Mark ;

Bathgate, Andrew ;

Burroughs, Andrew K. ;

Heneghan, Michael A. ;

Neuberger, James M. ;

Thorburn, Douglas ;

Hirschfield, Gideon M. ;

Cordell, Heather J. ;

Alexander, Graeme J. ;

Jones, David E. J. ;

Sandford, Richard N. ;

Mells, George F. .

HEPATOLOGY, 2016, 63 (03) :930-950

[5] Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid [J].

Carbone, Marco ;

Mells, George F. ;

Pells, Greta ;

Dawwas, Muhammad F. ;

Newton, Julia L. ;

Heneghan, Michael A. ;

Neuberger, James M. ;

Day, Darren B. ;

Ducker, Samantha J. ;

Sandford, Richard N. ;

Alexander, Graeme J. ;

Jones, David E. J. .

GASTROENTEROLOGY, 2013, 144 (03) :560-+

[6] A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis [J].

Corpechot, C. ;

Chazouilleres, O. ;

Rousseau, A. ;

Le Gruyer, A. ;

Habersetzer, F. ;

Mathurin, P. ;

Goria, O. ;

Potier, P. ;

Minello, A. ;

Silvain, C. ;

Abergel, A. ;

Debette-Gratien, M. ;

Larrey, D. ;

Roux, O. ;

Bronowicki, J. -P. ;

Boursier, J. ;

de Ledinghen, V. ;

Heurgue-Berlot, A. ;

Nguyen-Khac, E. ;

Zoulim, F. ;

Ollivier-Hourmand, I. ;

Zarski, J. -P. ;

Nkontchou, G. ;

Lemoinne, S. ;

Humbert, L. ;

Rainteau, D. ;

Lefevre, G. ;

de Chaisemartin, L. ;

Chollet-Martin, S. ;

Gaouar, F. ;

Admane, F. -H. ;

Simon, T. ;

Poupon, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (23) :2171-2181

[7] Early primary biliary cirrhosis: Biochemical response to treatment and prediction of long-term outcome [J].

Corpechot, Christophe ;

Chazouilleres, Olivier ;

Poupon, Raoul .

JOURNAL OF HEPATOLOGY, 2011, 55 (06) :1361-1367

[8] Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial [J].

de Vries, Elsemieke ;

Bolier, Ruth ;

Goet, Jorn ;

Pares, Albert ;

Verbeek, Jef ;

de Vree, Marleen ;

Drenth, Joost ;

van Erpecum, Karel ;

van Nieuwkerk, Karin ;

van der Heide, Frans ;

Mostafavi, Nahid ;

Helder, Jeltje ;

Ponsioen, Cyriel ;

Elferink, Ronald Oude ;

van Buuren, Henk ;

Beuers, Ulrich .

GASTROENTEROLOGY, 2021, 160 (03) :734-+

[9] Fibrates and cholestasis [J].

Ghonem, Nisanne S. ;

Assis, David N. ;

Boyer, James L. .

HEPATOLOGY, 2015, 62 (02) :635-643

[10] Fenofibrate is effective adjunctive therapy in the treatment of primary biliary cirrhosis: A meta-analysis [J].

Grigorian, Alla Y. ;

Mardini, Houssam E. ;

Corpechot, Christophe ;

Poupon, Raoul ;

Levy, Cynthia .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2015, 39 (03) :296-306

← 1 2 3 4 →