Convenient Method for the Production of Deuterium Gas Catalyzed by an Iridium Complex and Its Application to the Deuteration of Organic Compounds

被引：9

作者：

Enomoto, Akane ^{[1
]}

Kajita, Shunpei ^{[1
]}

Fujita, Ken-ichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Studies, Sakyo Ku, Kyoto 6068501, Japan

来源：

CHEMISTRY LETTERS | 2019年 / 48卷 / 02期

关键词：

Deuterium; Deuteration; Iridium; PLATINUM-GROUP METAL; C-H ACTIVATION; DEGRADATION METHOD; PD/C-ET3N SYSTEM; AMBIENT-PRESSURE; EXCHANGE; HYDROGEN; MILD; GENERATION; SOLVENTS;

D O I：

10.1246/cl.180870

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new protocol for the production of deuterium gas from easily-obtainable deuterated methanol and deuterium oxide has been developed. The reaction of deuterated methanol and deuterium oxide in the presence of an iridium catalyst bearing a functional bipyridonate ligand and sodium hydroxide under reflux for 48 hours gave deuterium gas in 63% yield. Deuteration reactions of unsaturated compounds and bromosubstituted aromatic compounds using the generated deuterium gas in the presence of palladium/charcoal catalyst were also investigated.

引用

页码：106 / 109

页数：4

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