Haematological recovery in poor and good haematopoietic stem cell mobilisers

ObjectivesEvaluate whether poor mobilisers had delayed haematopoietic (neutrophil and platelet) recovery despite receiving similar cell dose as good mobilisers. BackgroundAutologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies. This procedure requires HPC mobilisation from bone marrow to peripheral blood. Cell dose is important for a fast haematological recovery. Despite being poor mobilisers, some patients can collect enough cell numbers for transplantation. ResultsFifteen poor mobiliser patients (peak of CD34+ cells 10 mu L-1 in peripheral blood) were transplanted at our institution. Haematological recovery (neutrophil500 mu L-1) in this group was compared to that observed in the group of 16 patients of good mobilisers (peak of CD34+ cells 20 mu L-1 in peripheral blood) who received similar cell dose (263701744x10(6)kg(-1) vs 2727 +/- 01746x10(6)kg(-1); P=07177). The poor mobiliser group had neutrophil and platelet recovery later than the good mobiliser group (on day 12, range 9-14 vs day 10, range 9-22, P=00381 for neutrophil, and on day 2289 +/- 1116 and 1408 +/- 4821, P=00193 for platelet). Mortality rates and transfusion requirements were not different between the groups. Conclusion Poor mobilisers have delayed neutrophil and platelet recovery after autologous HPC transplantation despite having received the same cell dose as good mobilisers.