Synthesis of MRI contrast agent by coating superparamagnetic iron oxide with chitosan

被引：58

作者：

Lee, H ^{[1
]}

Shao, HP

Huang, YQ

Kwak, B

机构：

[1] Korea Inst Geol Min & Mat, Taejon 305350, South Korea

[2] Chungnam Natl Univ, Dept Mat Engn, Res Ctr Adv Magnet Mat, Taejon 305764, South Korea

[3] Chung Ang Univ Hosp, Coll Med, Dept Radiol, Seoul 156756, South Korea

来源：

IEEE TRANSACTIONS ON MAGNETICS | 2005年 / 41卷 / 10期

关键词：

in vivo; magnetic resonance imaging (MRI) contrast agent; nano-size; sonochemistry; ultrasuperpara magnetic iron oxide (USPIO)-chitosan;

D O I：

10.1109/TMAG.2005.855338

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Ultrasuperpara magnetic iron oxide (USPIO) nanoparticles were synthesized with iron chloride using a sonochemical method. The size of the USPIO nanoparticles was controlled by ultrasonic exposure time and power. The USPIO nanoparticles had a narrow size distribution, a perfect magnetite crystal structure, and high saturation magnetization. The magnetic resonance imaging (MRI) contrast agent was prepared by coating the USPIO and dispersing it with biocompatible chitosan. In vivo testing in New Zealand white rabbits confirmed the effectiveness of the USPIO nanoparticles as a MRI contrast agent.

引用

页码：4102 / 4104

页数：3

共 14 条

[1]

Berkovsky B.M., 1993, Magnetic Fluids: Engineering Applications

[2]

Cullity B. D., ELEMENTS XRAY DIFFRA

[3] Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible [J].

Jiang, WQ ;

Yang, HC ;

Yang, SY ;

Horng, HE ;

Hung, JC ;

Chen, YC ;

Hong, CY .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2004, 283 (2-3) :210-214

[4] Toxic effects of ionic magnetic fluids in mice [J].

Lacava, ZGM ;

Azevedo, RB ;

Lacava, LM ;

Martins, EV ;

Garcia, VAP ;

Rébula, CA ;

Lemos, APC ;

Sousa, MH ;

Tourinho, FA ;

Morais, PC ;

Da Silva, MF .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :90-95

[5] Biological effects of magnetic fluids:: toxicity studies [J].

Lacava, ZGM ;

Azevedo, RB ;

Martins, EV ;

Lacava, LM ;

Freitas, MLL ;

Garcia, VAP ;

Rébula, CA ;

Lemos, APC ;

Sousa, MH ;

Tourinho, FA ;

Da Silva, MF ;

Morais, PC .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 201 :431-434

[6] Applications of magnetic nanoparticles in biomedicine [J].

Pankhurst, QA ;

Connolly, J ;

Jones, SK ;

Dobson, J .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R167-R181

[7] MRI with superparamagnetic iron oxide: Efficacy in the detection and characterization of focal hepatic lesions [J].

Poeckler-Schoeniger, C ;

Koepke, J ;

Gueckel, F ;

Sturm, J ;

Georgi, M .

MAGNETIC RESONANCE IMAGING, 1999, 17 (03) :383-392

[8] Preparation and antibacterial activity of chitosan nanoparticles [J].

Qi, LF ;

Xu, ZR ;

Jiang, X ;

Hu, CH ;

Zou, XF .

CARBOHYDRATE RESEARCH, 2004, 339 (16) :2693-2700

[9] MRI of osteonecrosis [J].

Saini, A ;

Saifuddin, A .

CLINICAL RADIOLOGY, 2004, 59 (12) :1079-1093

[10] SONOCHEMICAL SYNTHESIS OF AMORPHOUS IRON [J].

SUSLICK, KS ;

CHOE, SB ;

CICHOWLAS, AA ;

GRINSTAFF, MW .

NATURE, 1991, 353 (6343) :414-416

← 1 2 →