Advanced injectable hydrogels for cartilage tissue engineering

被引：45

作者：

Zhu, Senbo ^{[1
,2
,3
]}

Li, Yong ^{[4
]}

He, Zeju ^{[1
,2
,3
]}

Ji, Lichen ^{[1
,2
,3
]}

Zhang, Wei ^{[1
]}

Tong, Yu ^{[1
]}

Luo, Junchao ^{[1
]}

Yu, Dongsheng ^{[1
]}

Zhang, Qiong ^{[5
]}

Bi, Qing ^{[1
,2
,3
]}

机构：

[1] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Rehabil Med,Dept Orthoped, Hangzhou, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthoped, Wenzhou, Peoples R China

[3] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China

[4] Zhejiang Univ Technol, Hangzhou, Peoples R China

[5] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Operating Room,Dept Nursing, Hangzhou, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

injectable hydrogels; tissue engineering; cartilage defect; osteoarthritis; advanced; MESENCHYMAL STEM-CELLS; HYALURONIC-ACID HYDROGEL; ARTICULAR-CARTILAGE; NANOCOMPOSITE HYDROGELS; CROSS-LINKING; PROGENITOR CELLS; DRUG-DELIVERY; GENE-THERAPY; THERMOSENSITIVE HYDROGEL; BIOMIMETIC SCAFFOLDS;

D O I：

10.3389/fbioe.2022.954501

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The rapid development of tissue engineering makes it an effective strategy for repairing cartilage defects. The significant advantages of injectable hydrogels for cartilage injury include the properties of natural extracellular matrix (ECM), good biocompatibility, and strong plasticity to adapt to irregular cartilage defect surfaces. These inherent properties make injectable hydrogels a promising tool for cartilage tissue engineering. This paper reviews the research progress on advanced injectable hydrogels. The cross-linking method and structure of injectable hydrogels are thoroughly discussed. Furthermore, polymers, cells, and stimulators commonly used in the preparation of injectable hydrogels are thoroughly reviewed. Finally, we summarize the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.

引用

页数：26

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