Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy

被引：149

作者：

Chun, Tae-Wook ^{[1
]}

Murray, Danielle ^{[1
]}

Justement, J. Shawn ^{[1
]}

Hallahan, Claire W. ^{[2
]}

Moir, Susan ^{[1
]}

Kovacs, Colin ^{[3
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA

[3] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INTENSIFICATION; GUT; REPLICATION; ACTIVATION; BURDEN;

D O I：

10.1093/infdis/jir208

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Residual plasma viremia (<50 copies/mL) persists in certain human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4(+) T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.

引用

页码：135 / 138

页数：4

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