Promoting Effects of Titanium Implants Coated with Dipterocarpus tuberculatus Extract on Osseointegration

被引：8

作者：

Jung, Jaewon ^{[1
,2
]}

Choi, Yun Ju ^{[1
,2
]}

Lee, Su Jin ^{[1
,2
]}

Choi, Yu-Sang ^{[3
]}

Douangdeuane, Bounleuane ^{[4
]}

Souliya, Onevilay ^{[4
]}

Jeong, Suhui ^{[1
,2
]}

Park, Sohae ^{[1
,2
]}

Hwang, Dae Youn ^{[1
,2
]}

Seo, Sungbaek ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Coll Nat Resources, Dept Biomat Sci, BK2I Four Program, Miryang 50463, South Korea

[2] Pusan Natl Univ, Life Sci Life & Ind Convergence Res Inst, Miryang 50463, South Korea

[3] DENTIS, Daegu 41065, South Korea

[4] Minist Hlth, Inst Tradit Med, Viangchan 0103, Laos

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2022年 / 8卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

osseointegration; Dipterocarpus tuberculatus; titanium implant; adhesion; SURFACE MODIFICATION; ORAL IMPLANTS; DIFFERENTIATION; PROLIFERATION; OSTEOGENESIS; EXPRESSION; CHEMISTRY; FAK;

D O I：

10.1021/acsbiomaterials.1c01220

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Titanium (Ti) is the most commonly used biomaterial for dental implants. When inserting Ti implants into jawbones, the main issue is the lack of strong bonding between the Ti implant and the host bone (osseointegration). Inspired by the outstanding adhesion performance of natural phenolic compounds on metal substrates and promoting effect for cell adhesion, we coated a natural plant extract, Dipterocarpus tuberculatus (MED), on Ti implants. We tested three groups of Ti plates and screwshaped fixtures: nontreated Ti as commercially produced, ozonetreated Ti as commonly used surface modification for dental implants, and MED-coated Ti. Interestingly, the MED coating on the Ti plate preserved the surface wetting property for 20 days, whereas the hydrophilic wetting of ozone-treated Ti was readily transformed to hydrophobic within a day. Computerized tomography and histopathological analysis revealed that MED coating enhanced new bone tissue formation and regeneration. The gene expression level of integrin as a bone cell adhesion receptor and its downstream key regulators was significantly increased than that of ozone-treated Ti. Therefore, we suggest considering MED-mediated cell signaling pathways in screening natural products for cell adhesion and osseointegration, and MED as a suitable coating agent for improving Ti implantation.

引用

页码：847 / 858

页数：12

共 35 条

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