Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light

被引:117
作者
Jeffes, EW [1 ]
McCullough, JL
Weinstein, GD
Kaplan, R
Glazer, SD
Taylor, JR
机构
[1] Univ Calif Irvine, Dept Dermatol, Irvine, CA 92697 USA
[2] Vet Affairs Med Ctr, Long Beach, CA USA
[3] Vet Affairs Med Ctr, Miami, FL 33125 USA
关键词
D O I
10.1067/mjd.2001.114288
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Aminolevulinic acid hydrochloride (ALA, Levulan) applied topically to actinic keratoses (AKs) leads to accumulation of the photosensitizer protoporphyrin M, which, when activated by exposure to light, eradicates AKs. Objective: We examined the safety and efficacy of photodynamic therapy using topical 20% ALA in a solution formulation and varying blue light doses to treat multiple AKs on the face and scalp. Method: This is a multicenter, investigator-blinded, randomized, vehicle-controlled study. Results: Thirty-six patients with clinically typical AKs were treated with 20% ALA; 14 to 18 hours later they were irradiated with a nonlaser fluorescent blue Light source. With the optimal light dose of 10 J/cm(2), 88% of the AKs completely cleared 8 weeks after a single photodynamic treatment, compared with 6% after treatment with vehicle and light. Conclusion: Topical ALA PDT using a nonlaser, blue Light source is an effective treatment for multiple AKs.
引用
收藏
页码:96 / 104
页数:9
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