Iron and thrombosis

被引:119
作者
Franchini, Massimo [1 ]
Targher, Giovanni [2 ]
Montagnana, Martina [3 ]
Lippi, Giuseppe [3 ]
机构
[1] Serv Immunoematol & Trasfus, Ctr Emofilia, Ospedale Policlin, I-37134 Verona, Italy
[2] Univ Verona, Dipartimento Sci Biomed & Chirurg, Sez Endocrinol & Malattie Metab, I-37100 Verona, Italy
[3] Univ Verona, Dipartimento Sci Biomed & Morfol, Ist Chim & Microscopia Clin, I-37100 Verona, Italy
关键词
iron; thrombosis; anemia;
D O I
10.1007/s00277-007-0416-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although essential for cell physiology, an increase or depletion of body iron has harmful effects on health. Apart from iron deficiency anemia and iron overload-related organ tissue damage, there are increasing evidences that body iron status is implicated in atherosclerotic cardiovascular diseases. The hypothesis formulated in 1981 that iron depletion may protect against cardiovascular events is intriguing and has generated a significant debate in the last two decades. Indeed, to study this phenomenon, several investigators have tried to design appropriate experimental and clinical studies and to identify useful biochemical and genetic markers of iron status. The results of the literature on the effect of iron deficiency and overload on vascular health are critically reviewed in this study from a pathogenic and clinical point of view.
引用
收藏
页码:167 / 173
页数:7
相关论文
共 95 条
[1]   Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis [J].
Akan, H ;
Güven, N ;
Aydogdu, I ;
Arat, M ;
Beksaç, M ;
Dalva, K .
ACTA HAEMATOLOGICA, 2000, 103 (03) :152-156
[2]   Carotid artery thrombus associated with severe iron-deficiency anemia and thrombocytosis [J].
Akins, PT ;
Glenn, S ;
Nemeth, PM ;
Derdeyn, CP .
STROKE, 1996, 27 (05) :1002-1005
[3]   IRON-DEFICIENCY ANEMIA, THROMBOCYTOSIS, AND CEREBROVASCULAR ACCIDENT [J].
ALEXANDER, MB .
SOUTHERN MEDICAL JOURNAL, 1983, 76 (05) :662-663
[4]   CEREBRAL SINUS THROMBOSIS IN PATIENTS WITH SEVERE IRON-DEFICIENCY ANEMIA DUE TO MYOMA UTERI [J].
AOKI, N ;
SAKAI, T .
ACTA NEUROCHIRURGICA, 1989, 97 (3-4) :131-134
[5]   IRON OVERLOAD AUGMENTS THE DEVELOPMENT OF ATHEROSCLEROTIC LESIONS IN RABBITS [J].
ARAUJO, JA ;
ROMANO, EL ;
BRITO, BE ;
PARTHE, V ;
ROMANO, M ;
BRACHO, M ;
MONTANO, RF ;
CARDIER, J .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (08) :1172-1180
[6]  
Ascherio A, 2001, CIRCULATION, V103, P52
[7]  
Auer J, 2002, NUTR METAB CARDIOVAS, V12, P285
[8]   Deep cerebral vein thrombosis associated with iron deficiency anaemia in adults [J].
Balci, Kemal ;
Utku, Ufuk ;
Asil, Talip ;
Buyukkoyuncu, Nilufer .
JOURNAL OF CLINICAL NEUROSCIENCE, 2007, 14 (02) :181-184
[9]   Haemochromatosis gene mutations and risk of coronary artery disease [J].
Battiloro, E ;
Ombres, D ;
Pascale, E ;
D'Ambrosio, E ;
Verna, R ;
Arca, M .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2000, 8 (05) :389-392
[10]  
Beguin Y, 1999, HAEMATOLOGICA, V84, P541