Effects of Air Pollution on Cellular Senescence and Skin Aging

被引：56
作者：
Martic, Ines [1 ,2 ]
Jansen-Duerr, Pidder [1 ,2 ]
Cavinato, Maria [1 ,2 ]
机构：
[1] Univ Innsbruck, Inst Biomed Aging Res, A-6020 Innsbruck, Austria
[2] Ctr Mol Biosci Innsbruck CMBI, Innrain 58, A-6020 Innsbruck, Austria
来源：
CELLS | 2022年 / 11卷 / 14期
基金：
奥地利科学基金会;
关键词：
senescence; air pollution; skin aging; cosmetics; ARYL-HYDROCARBON RECEPTOR; AIRBORNE PARTICULATE MATTER; OXIDATIVE STRESS; TNF-ALPHA; PREMATURE SENESCENCE; MOLECULAR-MECHANISMS; DERMAL FIBROBLASTS; EXPOSURE; AUTOPHAGY; OZONE;
D O I：
10.3390/cells11142220
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin and is known to promote aging and inflammation of this tissue, leading to the onset of skin disorders and to the appearance of wrinkles and pigmentation issues. Besides this, components of air pollution can interact synergistically with ultraviolet light and increase the impact of damage to the skin. However, little is known about the modulation of air pollution on cellular senescence in skin cells and how this can contribute to skin aging. In this review, we are summarizing the current state of knowledge about air pollution components, their involvement in the processes of cellular senescence and skin aging, as well as the current therapeutic and cosmetic interventions proposed to prevent or mitigate the effects of air pollution in the skin.
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页数：19
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