Effect of bilateral oophorectomy on wound healing of the rabbit vagina

被引：11

作者：

Abramov, Yoram ^{[1
]}

Webb, Antonio R. ^{[2
]}

Botros, Sylvia M. ^{[3
]}

Goldberg, Roger P. ^{[3
]}

Ameer, Guillermo A. ^{[2
]}

Sand, Peter K. ^{[3
]}

机构：

[1] Technion Univ, Rappaport Fac Med, Carmel Med Ctr, Dept Obstet & Gynecol,Div Urogynecol & Reconstruc, Haifa, Israel

[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[3] Univ Chicago, Pritzker Sch Med, Evanston Continence Ctr, Div Urogynecol & Reconstruct Pelv Surg, Evanston, IL USA

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 04期

关键词：

Biomechanical properties; estrogen deficiency; menopause; oophorectomy; tensile energy; tensile strength; vagina; wound healing; Young's modulus; MODIFIED TETRACYCLINE CMT-8; OVARIECTOMIZED RATS; TENSILE-STRENGTH; ESTROGEN; COLLAGEN; MODEL; MODULATION;

D O I：

10.1016/j.fertnstert.2010.08.001

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits. (Fertil Steril (R) 2011;95:1467-70. (C)2011 by American Society for Reproductive Medicine.)

引用

页码：1467 / 1470

页数：4

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