Association of Amyotrophic Lateral Sclerosis and Alzheimer's Disease: New Entity or Coincidence? A Case Series

被引：7

作者：

Vrillon, Agathe ^{[1
,2
]}

Deramecourt, Vincent ^{[3
]}

Pasquier, Florence ^{[3
]}

Magnin, Eloi ^{[4
,5
]}

Wallon, David ^{[6
,7
]}

Lozeron, Pierre ^{[8
]}

Bouaziz-Amar, Elodie ^{[2
,9
]}

Paquet, Claire ^{[2
,10
]}

机构：

[1] AP HP, GHU Nord Lariboisiere Fernand Widal, Cognit Neurol Ctr, Paris, France

[2] Univ Paris, INSERM, UMR S1144 Optimizat Neuropsycho, Paris, France

[3] Univ Lille, INSERM, CNRMAJ, CHU Lille Lille Neurosci & Cognit,LiCEND,DistAlz, Lille, France

[4] Univ Hosp Besancon, Dept Neurol, Besancon, France

[5] Bourgogne Franche Comte Univ, Clin & Integrat Neurosci, Res Lab 481, Besancon, France

[6] Normandie Univ, Rouen Univ Hosp, UNIROUEN, Dept Neurol,Inserm U1245, Rouen, France

[7] Normandy Ctr Genom & Personalized Med, CNR MAJ, CIC CRB1404, Rouen, France

[8] Hop Lariboisiere, AP HP, Serv Physiol Clin Explorat Fonctionnelles, Paris, France

[9] AP HP, GHU Nord Lariboisiere Fernand Widal, Serv Biochim & Biol Mol, Paris, France

[10] AP HP, GHU Nord Lariboisiere Fernand Widal, Ctr Neurol Cognit, Paris, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 84卷 / 04期

关键词：

Alzheimer's disease; amyotrophic lateral sclerosis; cerebrospinal fluid biomarkers; neurodegenerative disorders; neuropathology; FRONTOTEMPORAL DEMENTIA; COGNITIVE PROFILE; ALS; COMPLEX; REGION; TDP-43; GUAM;

D O I：

10.3233/JAD-215226

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer's disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.

引用

页码：1439 / 1446

页数：8

共 38 条

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