Intravenous administration of alendronate counteracts the in vivo effects of glucocorticoids on bone remodeling

被引：40

作者：

Falcini, F ^{[1
]}

Trapani, S ^{[1
]}

Ermini, M ^{[1
]}

Brandi, ML ^{[1
]}

机构：

[1] UNIV FLORENCE,SCH MED,DEPT PHYSIOPATHOL,ENDOCRINE UNIT,I-50121 FLORENCE,ITALY

来源：

CALCIFIED TISSUE INTERNATIONAL | 1996年 / 58卷 / 03期

关键词：

alendronate; steroids; osteoporosis; rheumatic diseases;

D O I：

10.1007/BF02526882

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of the investigation was to test the use of alendronate in the therapy of children affected by chronic rheumatic diseases and symptomatic drug-induced osteoporosis. Two courses of alendronate were intravenously administered to four girls with vertebral fractures that were glucocorticoid induced. Improvement of back pain and bone mineral density increase evaluated by DXA and conventional spine X-rays were observed. Our study supports the ABD-induced improvement of the negative effects of long-term therapy on bone mineral density in children with chronic rheumatic diseases.

引用

页码：166 / 169

页数：4

共 22 条

[1] CORTICOSTEROID-INDUCED OSTEOPOROSIS [J].

ADACHI, JD ;

BENSEN, WG ;

HODSMAN, AB .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1993, 22 (06) :375-384

[2]

BIJVOET OLM, 1993, OSTEOPOROSIS INT, V3, pS230

[3]

BONUCCI E, 1984, ADV EXP MED BIOL, V171, P269

[4] PROSPECTIVE USE OF BISPHOSPHONATES IN OSTEOPOROSIS [J].

FLEISCH, H .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (06) :1397-1398

[5]

FLEISCH H, 1993, OSTEOPOROSIS INT, V3, pS15

[6] BISPHOSPHONATES - PHARMACOLOGY [J].

FLEISCH, H .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1994, 23 (04) :261-262

[7]

Gallacher S. J., 1993, Calcified Tissue International, V52, pS74

[8] INTRAVENOUS PAMIDRONATE IN THE TREATMENT OF OSTEOPOROSIS ASSOCIATED WITH CORTICOSTEROID DEPENDENT LUNG-DISEASE - AN OPEN PILOT-STUDY [J].

GALLACHER, SJ ;

FENNER, JAK ;

ANDERSON, K ;

BRYDEN, FM ;

BANHAM, SW ;

LOGUE, FC ;

COWAN, RA ;

BOYLE, IT .

THORAX, 1992, 47 (11) :932-936

[9] CHARACTERISTICS AND BISPHOSPHONATE TREATMENT OF A PATIENT WITH JUVENILE OSTEOPOROSIS [J].

HOEKMAN, K ;

PAPAPOULOS, SE ;

PETERS, ACB ;

BIJVOET, OLM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (05) :952-956

[10]

Lombardi A, 1992, Ann Ital Med Int, V7, p158S

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