Keep it in the subfamily: the conserved alphaherpesvirus US3 protein kinase

被引：52

作者：

Deruelle, M. J. ^{[1
]}

Favoreel, H. W. ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, Ghent, Belgium

来源：

JOURNAL OF GENERAL VIROLOGY | 2011年 / 92卷

关键词：

HERPES-SIMPLEX-VIRUS; VARICELLA-ZOSTER-VIRUS; TRANSCRIPTIONAL REGULATORY PROTEIN; TO-CELL SPREAD; STRESS FIBER BREAKDOWN; EFFICIENT VIRAL GROWTH; OUTER NUCLEAR-MEMBRANE; MAREKS-DISEASE VIRUS; COMPLEX CLASS-I; PSEUDORABIES VIRUS;

D O I：

10.1099/vir.0.025593-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The US3 protein kinase is conserved over the alphaherpesvirus subfamily. Increasing evidence shows that, although the kinase is generally not required for virus replication in cell culture, it plays a pivotal and in some cases an essential role in virus virulence in vivo. The US3 protein is a multifunctional serine/threonine kinase that is involved in viral gene expression, virion morphogenesis, remodelling the actin cytoskeleton and the evasion of several antiviral host responses. In the current review, both the well conserved and virus-specific functions of alphaherpesvirus US3 protein kinase orthologues will be discussed.

引用

页码：18 / 30

页数：13

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