Orphan nuclear receptor RZR beta: Cyclic AMP regulates expression in the pineal gland

被引：37
作者：
Baler, R [1 ]
Coon, S [1 ]
Klein, DC [1 ]
机构：
[1] NICHHD,NIH,DEV NEUROBIOL LAB,SECT NEUROENDOCRINOL,BETHESDA,MD 20892
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 03期
关键词：
D O I：
10.1006/bbrc.1996.0517
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nuclear orphan receptor RZR beta is highly expressed in the rat pineal gland. Recent studies proposed that melatonin, the pineal hormone which regulates a wide variety of circadian-linked phenomena, may be the natural ligand of this receptor. These provocative reports prompted us to learn more about RZR beta and how it might function in circadian physiology. Here we confirm high expression of this receptor in the pineal gland, and report that pineal RZR beta expression exhibits a strong daily rhythm. Expression is under photoneural regulation and involves an adrenergic --> cAMP mechanism. (C) 1996 Academic Press, Inc.
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收藏
页码：975 / 978
页数：4
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