MULTIPLE PERIODIC SOLUTIONS OF A WITHIN-HOST MALARIA INFECTION MODEL WITH TIME DELAY

In this paper, we study a within-host malaria infection model recently proposed by Schneider et al. in 2018. The stability and Hopf bifurcation analysis at the interior equilibrium are carried out, finding that the basic reproduction number plays a key role in the dynamics of the model, and incrementing the time delay will induce Hopf bifurcation at this equilibrium. The global extension of the local Hopf branch is further tracked numerically by the MatLab package DDE-BIFTOOL. Neimark-Sacker bifurcation of Poincare map and period-doubling bifurcation of the bifurcated periodic solution are also detected, resulting in the existence of quasi-periodic and multiple periodic solutions, respectively. These results reveal that Hopf bifurcation will indeed bring about the rich dynamics of the model.