Genes co-amplified with MYCN in neuroblastoma:: silent passengers or co-determinants of phenotype?

被引：30
作者：
Scott, D
Elsden, J
Pearson, A
Lunec, J
机构：
[1] Univ Newcastle Upon Tyne, Sch Med, Canc Res Unit, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Royal Victoria Infirm, Dept Child Hlth, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
来源：
CANCER LETTERS | 2003年 / 197卷 / 1-2期
关键词：
neuroblastoma; MYCN; co-amplification; 2p24; NAG; DDX1;
D O I：
10.1016/S0304-3835(03)00086-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Amplification of the MYCN oncogene in neuroblastoma is associated with poor prognosis. The amplified unit of DNA can be up to 1 Mb in size and so could contain additional genes that affect tumour phenotype. Identification of such genes may assist in optimising the determination of prognosis, and could provide new targets for treatment. Three genes have so far been identified, which are frequently co-amplified with MYCN in neuroblastoma, DDX1, NAG and N-cym. In this review, the known or putative properties of the protein products of the genes are discussed, and their possible roles in determining tumour behaviour are assessed. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
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