Decoding the complexity of circular RNAs in cardiovascular disease

被引：16
作者：
Rai, Amit Kumar [1 ]
Lee, Brooke [1 ]
Hebbard, Carleigh [1 ]
Uchida, Shizuka [2 ]
Garikipati, Venkata Naga Srikanth [1 ,3 ]
机构：
[1] Ohio State Univ, Dept Emergency Med, Wexner Med Ctr, Columbus, OH USA
[2] Aalborg Univ, Ctr RNA Med, Dept Clin Med, DK-2450 Copenhagen SV, Denmark
[3] Ohio State Univ, Dorothy M Davis Heart Lung & Res Inst, Wexner Med Ctr, Columbus, OH USA
来源：
PHARMACOLOGICAL RESEARCH | 2021年 / 171卷
关键词：
Circular RNA; Cardiovascular Disease; RNA binding proteins and micro RNA; MYOCARDIAL-INFARCTION; CARDIAC-FUNCTION; TRANSLATION; BIOGENESIS; MECHANISMS; EXPRESSION; CIRCRNA; BINDING; HEART; GENE;
D O I：
10.1016/j.phrs.2021.105766
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.
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页数：12
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